Healthcare Compliance, Automated: Onyxia’s New Pre-Built HITRUST Custom Framework

For healthcare Chief Information Security Officers (CISOs) and security leaders, the stakes of data protection have never been higher. Healthcare remains the number one targeted critical infrastructure sector, and the sophistication of those attacks is escalating at a dizzying pace.

According to HITRUST’s recently released Quarterly Cyber Threat Adaptive Analysis, adversaries are rapidly accelerating their use of AI-driven attack techniques. Phishing and social engineering campaigns, now heavily enhanced by generative AI, continue to dominate initial access points. Concurrently, attackers are aggressively exploiting external remote services, internet-facing systems, and unpatched web applications to gain unauthorized footholds. Static compliance checklists are no longer enough to defend against a threat landscape moving at the speed of AI.

To maintain operational resilience, organizations need a framework that is as dynamic as the threats they face. The HITRUST Common Security Framework (CSF) is widely recognized as the gold standard for healthcare risk management because it is threat-adaptive, continually mapping controls back to real-world MITRE ATT&CK® techniques. However, because it spans hundreds of prescriptive specifications across hybrid environments, managing it manually has historically been an administrative headache.

Today, we are thrilled to eliminate that friction. Onyxia’s platform now includes a pre-built HITRUST template within our Custom Compliance Frameworks module. By bridging the gap between high-level compliance and real-time security data, Onyxia empowers healthcare organizations to stop checking boxes and start building data-driven cyber resilience.

HITRUST CSF Custom Framework Mapping in the Onyxia Platform

The Power of Tailored Governance: Custom Compliance Frameworks

No two organizations share the exact same risk profile, security architecture, or regulatory burdens. Onyxia’s Custom Frameworks capability enables CISOs to design a cybersecurity program management framework that fits their organization’s specific regulatory requirements.

Whether you are starting entirely from scratch or deploying one of our pre-built templates, the platform gives you full control. Users can easily adjust their cybersecurity program categories, weights, and Cyber Performance Indicators (CPIs) to accurately measure and demonstrate compliance with key frameworks—including NIST 2.0, HIPAA, SOC 2, PCI, and now, HITRUST.

By deploying the pre-built HITRUST template into this customizable environment, security teams unlock three major benefits:

  • Better Compliance Tracking with Customizable Frameworks: Move away from monolithic, rigid tracking. Tailor the HITRUST template to match your organization’s unique operational scope, cloud environment, and size-appropriate controls.

  • Improved Alignment of Cybersecurity Performance Data: Onyxia automatically ingests live telemetry from across your entire security stack, mapping your actual tools to HITRUST's prescriptive controls. You instantly see where your software is working and where blind spots or coverage gaps leave you exposed to AI-enabled exploits.

  • Streamlined Reporting of Compliance Efforts: Easily meet stringent disclosure regulations and demonstrate continuous readiness to executive stakeholders and external auditors. Instead of spending weeks scrambling for evidence before an audit, you maintain a continuous, auditable record of your security posture.

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Move from Reactive Firefighting to Operational Resilience

As adversaries weaponize automation and generative AI, treating compliance as an annual, retroactive exercise leaves your organization vulnerable. True security requires continuous, data-driven visibility.

With Onyxia’s new pre-built HITRUST template and Custom Compliance Frameworks, you can dynamically align your defenses with the gold standard of protection, saving time, maximizing your current security stack investments, and proactively defending patient data.

Ready to see how your current security stack maps against the HITRUST framework? Book a demo with the Onyxia team today to experience automated, continuous compliance mapping firsthand.

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